Abstract
Purple rice (Oryza sativa L. indica) has been shown to have anti-hyperglycemic activity. However, the underlying mechanism of the anti-hyperglycemic activity of purple rice is still unknown. To explore this mechanism, we studied the protein profiling of the liver tissues of normal rats, normal rats with purple rice bran supplementation, type 2 diabetic rats, type 2 diabetic rats with purple rice bran supplementation, and type 2 diabetic rats with metformin treatment by using onedimensional gel electrophoresis and quantitative LC-MS/MS analysis. Eight proteins and five proteins were solely expressed in type 2 diabetic rats and type 2 diabetic rats with purple rice bran supplementation respectively. The unique proteins in the diabetic rats correlated with the fatty acid synthesis, supporting the view that abnormal lipid metabolism and hyperlipidemia are complications of diabetes. The unique proteins in the diabetic rats with purple rice bran supplementation correlated with the insulin signaling pathway, suggesting that purple rice bran might improve insulin sensitivity. Interestingly, 11 proteins co-expressed in both normal control rats and type 2 diabetic rats with purple rice bran supplementation involved in oxidative stress response and autophagy. Our study might help to unveil the molecular mechanism involved in the anti-diabetic activity of purple rice
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