Abstract
AbstractGeneralized tonic‐clinic seizures may appear as a side‐effect of all antidepressant drugs, including mianserin. We present here a case of an 83‐year‐old woman whose major depressive episode (superimposed on mild dementia) completely resolved following a generalized tonic‐clonic seizure. The improvement, which was maintained for 3 months, may be attributable to the drug‐induced single convulsion. It would be of interest to know whether other psychiatrists have had similar experiences concerning an immediate antidepressant effect to a single tonic‐clonic seizure (drug‐induced or provoked by electroconvulsive therapy). If a subgroup of patients responsive to single generalized tonic‐clonic seizure were to exist (especially among elderly patients), it would allow them to receive a minimal number of electroconvulsive therapy (ECT) sessions, decreasing the probability of the appearance of ECT side‐effects.
Published Version
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