Abstract
PurposeThis study aimed to determine whether short small intestine modifies antidepressant concentrations. MethodsThe Css values and concentration–dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome. FindingsEight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low Css values, including 1 patient who received intravenous treatment. ImplicationsThe variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.
Published Version
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