Abstract
Objective: The study was aimed to evaluate and compare the anticonvulsant activity of aqueous leave extract of Portulaca oleracea Linn. and Eupatorium brimanicum DC in MES model in albino mice.
 Methods: Aqueous Extracts were prepared by the soxhlet extraction method. MES model was chosen to evaluate anticonvulsant activity. 36 albino mice were selected and divided into 6 groups for this model. Group I received 2% gum acacia 1 ml/100 g orally. Group II received phenytoin-20 mg/kg orally. Group III and IV received 200 and 400 mg/kg of Portulaca oleracea Linn. Respectively. Group V and VI received 200 and 400 mg/kg of Eupatorium brimanicum DC respectively.
 Results: The extracts didn’t show any toxicity and significantly reduced hind limb tonic extension (HLTE) duration in MES model (50 mA, 0.2 sec) at higher doses.
 Conclusion: The results suggest Portulaca oleracea Linn. and Eupatorium brimanicum DC extract possess anticonvulsant activity and justify their use in folk medicine.
Highlights
Epilepsy is one of the most common neurological disorders which significantly affects the quality of life
The qualitative phytochemical analysis of Portulaca oleracea Linn. and Eupatorium brimanicum DC revealed the presence of alkaloids, flavonoids, saponins and tannins
Anti-convulsant effects of aqueous extract of Portulaca oleracea Linn. and Eupatorium brimanicum DC on Maximal electroshock (MES) induced seizure in mice are shown in table 2
Summary
Epilepsy is one of the most common neurological disorders which significantly affects the quality of life. It affects 70 million people in the world [1]. Antiepileptic drug therapy is the mainstay of treatment for most of patients of epilepsy. The drugs used currently fail to control seizure activity in approximately 30% of patients but frequently cause untoward effects like impairment of the CNS, aplastic anaemia, hepatic failure, etc [4, 5]. There is paucity of the anticonvulsant studies of the medicinal plants like Portulaca oleracea Linn. Our study aimed to evaluate the anticonvulsant activity of these two medicinal plants in Maximal electroshock (MES) model of epilepsy in albino mice
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