Abstract
Objective: Depression is an affective disorder characterized by a change in mood, lack of confidence, lack of interest in surroundings and many natural products that have been tried to treat the disease. The study was aimed to evaluate and compare the antidepressant activity of methanol leave extract of SapindusemarginatusVahl. (MESE) and Acoruscalamus Linn. (MEAC) in experimental models in albino mice.
 Methods: Methanol Extracts of the plants were prepared by soxhlet extraction method. Forced swimming test (FST) and Tail suspension test (TST) models were chosen to evaluate antidepressant activity.Albino mice were selected and divided into six groups of six animals for each experimental model. Group I received 1% gum acacia in distilled water (DW) at a dose of 1 ml/100 g orally. Group II received sertraline-10 mg/kg orally. Group III and IV were administered 200 and 400 mg/kg of MESE respectively. Group V and VI were treated with 200 and 400 mg/kg of MEAC, respectively.
 Results: Methanol extracts of Sapindusemarginatus and Acoruscalamus at the two different doses of 200 and 400 mg/kg demonstrated a significant decrease in immobility time when compared with the control in both animal models. The extracts at the higher dose of 400 mg/kg revealed a significant reduction in immobility time compared to 200 mg/kg of the same extract.
 Conclusion: The results suggest that the methanol extracts of SapindusemarginatusVahl. andAcoruscalamus Linn. possessthe anticonvulsant activityand justify their use in folk medicine.
Highlights
Depression is an affective disorder characterized by a change in the mood, lack of confidence, lack of interest in surroundings and the severity may range from mild to severe [1]
The preliminary qualitative phytochemical analysis of methanol extract of Sapindusemarginatusrevealed the presence of alkaloids, carbohydrates, flavonoids, saponins, tannins, gums and proteins, while the extract of Acoruscalamus revealed the presence of flavonoids, saponins, tannins, alkaloids and starch
The mean duration of immobility in various groups treated with control, Sertraline-10 mg/kg, methanol leave extract of SapindusemarginatusVahl. (MESE)-200 mg/kg, MESE-400 mg/kg, MEAC-200 mg/kg and MEAC-400 mg/kg were 177.67±15.83, 56.83±4.75, 93.67±13.11, 54.33±17.61, 110±6.38 and 63±13.08 respectively
Summary
Depression is an affective disorder characterized by a change in the mood, lack of confidence, lack of interest in surroundings and the severity may range from mild to severe [1]. Depression will become the second leading cause of premature death or disability worldwide by the year 2020.A large percentage of patients suffering from depression respond to the currently available antidepressants, but the extent of improvement is still disappointing because of various side effects and drug tolerance [2].Till today, there are many unmet clinical needs with respect to the efficacy and adverse effects of the variousantidepressants. To address these needs, antidepressants with novel mechanisms and fewer side effects are in great demand [3]. Forced Swim Test (FST) and Tail Suspension Test (TST) are employed as exemplary systems to probe depressing condition in rodents [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
