Abstract
The objective of this study was to investigate the anticonvulsant activity of 5-HT 3 antagonist, granisetron in albino mice. In this study granisetron (0.5mg/kg, i.p.) was administered 30 minutes prior to application of electroshock (60mA, 02.seconds) or administration of pentylenetetrazole. Granisetron significantly reduced the duration of tonic hind limb extension in maximum electroshock seizure (MES) test. In pentylenetetrazole (PTZ) test, granisetron delayed the onset and the decreased the duration of convulsions compared to control group. The percentage of animals protected in MES and PTZ models were 66 and 83 respectively. The results showed that granisetron at dose of 0.5mg possess anticonvulsant activity in both MES and PTZ models.
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