Abstract
The aim of the present study was to determine anti caries and α - amylase inhibitory activity of leaf extract of Jasminum arborescens Roxb. (Oleaceae). Anti caries activity was determined by Aga r well diffusion assay against seven clinical isolates of Streptococcus mutans (Sm - 01 to Sm - 07) recovered from dental caries subjects. Enzyme inhibitory activity was tested against α - amylase by s pectrophometric method using starch as substrate . The extract exhibited dose dependent inhibition against cariogenic isolates . Among seven isolates, isolate Sm - 04 and Sm - 06 were inhibited to higher and least extent respectively. The extract was found to ca use inhibition of α - amylase activity in a dose dependent manner and its IC 50 value was found to be 17.45 mg/ml . The inhibitory activity could be attributed to the presence of secondary metabolites. The plant may be a potential source for development of agents which are acti ve against dental caries pathogens and for diabetes mellitus.
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