Anticandidal activity of some Zn(II) and Pb(II) complexes

Abstract

The reactions of zinc and lead acetate with ligands HON=C(CH2)5, PhN=C(Ph)C(OH)Ph resulted in complexes of the type [M(ac)2L2] (M = Zn/Pb and L = corresponding ligand). Ligands were prepared by green methods. Complexes were characterized by proton-NMR, IR spectral studies and these spectra were compared with that of free ligands. Antifungal activity of the complexes demonstrated that the complexes [ZnII(ac)2{N(OH)=C(CH2)5}2], [PbII(ac)2{N(OH)=C(CH2)5}2] and [ZnII(ac)2{N(Ph)=C(Ph)C(OH)Ph}2] are active against Candida albicans.