Abstract
Introduction: Siddha system of medicine is one of the ancient Indian medical systems that is popularly known for the management and treatment of chronic noncommunicable diseases. Herbs and minerals constitute the major part of Siddha medicines. Herbs, herbal extracts, and minerals are commonly used to treat various malignancies. Pancha Paasana Chendhuram (PPC) is a herbo-mineral formulation used to treat different types of cancers in Siddha practice. Methods: In the present study, we investigated the in vitro antioxidant and anticancer activities of PPC against breast cancer cells (MCF-7). Results: PPC showed moderate antioxidant effects; it also showed a dose-dependent inhibition of MCF-7 cell proliferation, with an IC50 (half maximal inhibitory concentration) of 59.26 mg/mL and nuclear damage in cancer cells. PPC upregulated Bax and Bcl2 and downregulated p53 mRNA (messenger Ribonucleic acid) expression in MCF-7 cells. Conclusion: These results suggest that PPC may be an interesting candidate for further studies in treating breast cancer.
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