Abstract
SummaryAnticancer activity of the alkaloidal and non-alkaloidal neutral fractions of narcissus bulbs has been demonstrated against Ehrlich ascites tumor and #6C3HED solid lymphosarcoma cells in mice. The residual alkaloid also showed moderate activity against syngeneic MCDV-12 leukemia cells in BALB/c mice and the 5th subfraction of neutrals (N-5) enhanced the activity of cyclophosphamide against the cells although N-5 itself was not active. The single ip administration of the neutral fraction was enough to eradicate Ehrlich ascites cells in about 50% of mice, while the alkaloidal fraction needed multiple administrations to suppress tumor growth. The cytotoxicity of the narcissus agents on KB cells was also investigated.We thank Dr. M. A. Chirigos of NIH for helpful advice; Dr. R. J. Speer of Wadley Institutes, Texas, for testing on L1210 leukemia; and Dr. P. Yoder of University of Hawaii for supplying MCDV-12 leukemia cells and critical review of the manuscript.
Published Version
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