Abstract
Magnetic iron oxide nanoparticles (Cs-FeNPs) are increasingly being studied for potential anticancer applications to circumvent off-target cytotoxicity and other side effects from conventional chemotherapy. In this study chitosan aqueous extracts were used as natural stabilizers to synthesize Cs-FeNPs followed by a series of characterization experiments and in vitro anticancer evaluation. Morphological studies demonstrated that adding peel extract decreased the size of NPs with an average particle size below 100 nm. Cytotoxicity assay showed that the Cs-FeNPs were more reactive (IC50 29.759 µg/ml) against PC-3 cancer cell lines and normal Vero cell lines. Specifically, Cs-FeNPs displayed potent anticancer activities against PC-3 cell line. This study showed the characterization of eco-friendly synthesized Cs-FeNPs and their potential use as anticancer therapeutic agents against PC-3 cells.
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