Abstract
Iron oxides are the most common types of substances available in nature in various forms such as oxides, hydroxides and oxide-hydroxides, which obtained from various aqueous reactions. In the present study, iron oxide (Fe3O4) nanoparticles (NPs) had been synthesized using co - precipitation method and determined some biological activities. Iron oxide NPs had been characterized by spectrophotometry, X- Ray Diffraction (XRD) analysis and Field Emission Scanning Electron Microscopic (FE-SEM). The XRD analysis confirmed the purity and crystalline nature of fabricated NPs. In contrast, four biological activities of iron oxide NPs were determined. High removal of methylene blue pollutant dye (37.62 %) was observed when iron oxide NPs were used at 400 µg/ml within 48 hrs. Furthermore, iron oxide NPs revealed high inhibition zones of 27.5 and 30 mm, at 1000 µg/ml, toward Staphylococcus aureus and Escherichia coli respectively. The hemolysis activity of fabricated NPs is increases whenever concentrations increased. The lower hemolysis percentage of iron oxide NPs was (69.76%) when the NPs concentration was 250 µg/ml. Finally, cytotoxic activity was estimated against MCF- 7 cell line and normal cell line WRL68 by MTT assay. Significant and decrease in viability of (MCF-7 to 65.1%) when 400 µg/ml of iron oxide NPs was examined, while WRL68 viability was (75.03%).
Highlights
Metal oxide nanoparticles have exceptional properties that lead to great interest in some biological activities
Iron oxides are the most common types of substances available in nature in various forms such as oxides, hydroxides and oxide-hydroxides, which obtained from various aqueous reactions
Iron oxide NPs had been characterized by spectrophotometry, X- Ray Diffraction (XRD) analysis and Field Emission Scanning Electron Microscopic (FE-SEM)
Summary
Metal oxide nanoparticles have exceptional properties that lead to great interest in some biological activities. Iron (Fe) is a transitional mineral and the backbone of the earth's crust appeared in different forms and magnetic properties, either as hematite (α-Fe2O3), magnetite (Fe3O4) or maghemite (ɣ-Fe2O3) [1, 2]. Iron oxide NPs revealed more stable, superparamagnetic, biocompatible, and low toxicity compounds. They have high stability in water when exposed to difficult conditions such as high temperature and high pH, and their conjugation with biomolecules is very easy [4]. Iron oxide nanoparticles have amazing magnetic properties and high biocompatibility that have attracted widespread interest in the biomedical field [1, 6]. The aim of this study is determining their compatibility, the ability to remove pollutant dye, hemolysis, antibacterial and antitumor activities had been investigated
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