Abstract
The aim of the present work is the evaluation of anti cancer effect of Carica papaya aerial parts extracts and also the investigation of the phytoconstituents from the extracts of the plant. Petroleum ether (40-60 о C), Chloroform, ethyl acetate and methanol 80% extracts of C. papaya aerial parts were tested for their anti cancer activity on three cancer cells TK10 (renal), UACC62 (melanoma) and MCF7 (breast) cancer cells using a Sulforhodamine B (SRB) assay. Petroleum ether of C. papaya at the concentration of 100 µg/ml has shown a significant anticancer effect for MCF7 (breast) cancer cells and showed less anticancer effect for the other two cancer cells while the other extracts have mild anticancer effect on the three cancer cells. Phytochemical profile of the plant extracts proves the presence of flavonoids, tannins, alkaloids, carbohydrates and triterpenes and bioactive fractionation of petroleum ether extract revealed the isolation and identification of β-sitosterol, stigmasterol as the major constituents. The results suggest that petroleum ether extract of C. papaya exhibited a significant anti cancer activity for breast cancer.
Highlights
Cancer is a leading cause of death worldwide, it is a dreadful disease, and combating this disease is of great importance to public health
In our searching for new anticancer drugs from plants, Carica papaya Linn. from Caricaceae family known as pawpaw tree is a vegetable fruit widely distributed throughout the world, mostly grow in tropics and it grows up to 5 to 10 m tall (Duke, 1984)
The growth inhibitory effects of the extracts were tested in the 3-cell line panel consisting of TK10, UACC62 and MCF7 cancer cells using a Sulforhodamine B (SRB) assay
Summary
Cancer is a leading cause of death worldwide, it is a dreadful disease, and combating this disease is of great importance to public health. There is a necessity for search of new natural extracts of plant source and compounds with cytotoxic activity as the treatment of cancer with the available anticancer drugs is often unsatisfactory due to the problem cytotoxicity to the normal cells. The papaya fruit, as well as all other parts of the plant, contain a milky juice in which an active principle known as papain is present (Nisar et al, 2011). It has a good effect as a remedy in dyspepsia and kindred ailments. This study was carried out to evaluate anti cancer effect of C. papaya extracts on three cancer cells TK10 (renal), UACC62 (melanoma) and MCF7 (breast) cancer cells and to investigate the phytoconstituents of the plant extracts
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