Abstract
Anti-brush border antibody (ABBA) renal disease is a relatively under-reported cause of severe tubular injury in elderly patients. In ABBA, immune complexes deposit within the tubular basement membrane (TBM) of the proximal convoluted tubule (PCT), and Bowman’s capsule.1,2 A recent study reported that anti-low-density lipoprotein receptor-related protein 2 (LRP2, also known as megalin) is an auto-antibody in ABBA.1 The disease course often rapidly progresses to end stage kidney disease (ESKD). To date, only 11 cases have been reported.1–3
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