Antibody therapies in cancer and autoimmune disease

Abstract

Cancer and autoimmune diseases are gradually proven to be "two sides of the same coin". Many cancer patients develop manifestations of autoimmune diseases and rheumatism, especially those receiving immune checkpoint inhibitors. At the same time, patients with autoimmune diseases also have cancer combined, which may be related to chronic inflammation damage to DNA or clinical medication. Antibody therapies, pioneered by monoclonal antibody drugs, are now used extensively in the treatment of cancer and autoimmune diseases. The relationship between cancer and autoimmune diseases is gradually being discovered, and some antibody therapies have therapeutic effects on both types of diseases, perhaps because the two have common targets. In-depth study of the role of various targets in the occurrence and development of the two types of diseases, screen the common targets, and discover the antibody drugs that play an activation or inhibition role against the common targets, so as to achieve the effect of "same treatment for different diseases", which brings hope to patients with "cancer-autoimmune diseases". This paper discusses the relationship between the two types of diseases, summarizes the specific targets and corresponding diseases of some antibody therapies, and analyzes the current status of antibody therapy in the treatment of the two types of diseases, in order to explore the "dual therapy" potential of more antibody therapies in the future, and develop new targets and drugs.