Immunomodulation by helmintos: Possible use as therapy for autoimmune diseases

Abstract

Context: The incidence of autoimmune diseases and allergies has increased markedly in the last half of the 20th century, especially in more developed countries, with an increase in urbanization and hygiene that has led to the elimination of many parasitic infections. Objective: To analyze through scientific bibliographic sources the effects of the parasite load, especially helminthiasis, on the appearance of autoimmune and allergic diseases. Methodology: The documentary analysis of different scientific sources that refer to the theory of immunomodulation by helminths was used. Results: They suggest that the treatment of autoimmune diseases with helminths or products derived from them can have protective and therapeutic effects in these patients. Conclusions: It could be concluded that the immunodulation mechanisms carried out by helminths prevent patients from eliminating the parasites, but have beneficial effects on the course of some autoimmune diseases. Although the causal relationship is not fully proven, studies in animal models and clinical trials carried out in patients with autoimmune diseases suggest that their treatment with helminths or products derived from them may have protective and therapeutic effects in these patients.