Abstract
Summary The serum of rabbits which have been homografted with skin was shown to be toxic to the lymph node cells of the skin donor. Fresh serum was toxic, and the activity of the serum declined rapidly upon standing overnight, freezing or heating at 56°C for 30 min. The loss of activity could be restored to a large extent by addition of fresh normal rabbit serum or fresh serum from the lymphocyte donor rabbit. Guinea pig complement exerted some inherent toxicity. The possibility that the detection of such cytotoxins may suggest a re-evaluation of the cellular basis of homograft immunity is discussed.
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