Abstract
1. The specific objectives of the present investigation were at first two-fold: (1) to determine the antigenicity of the early chick embryo, and (2) to study the effects of homologous antisera on the chick embryo. However, because at the outset a profound toxic action of fresh normal rabbit serum was encountered, it became imperative to describe the toxic factor.2. The toxic action of normal rabbit serum, characterized by the puckering of the blastoderm, the sinking of the embryo and its ultimate death, was removed by heating at 56° C. for 30 minutes. The toxic action was not restored by adding fresh guinea pig serum to heated rabbit serum. The toxicity was not removed by absorption in the cold with nonspecific antigen-antibody precipitates and/or chicken red blood cells. These results are interpreted as indicating that complement is neither necessary nor sufficient for the toxic action of fresh rabbit serum. The toxic heat-labile substance can also act independently of heat-stable substances which are re...
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