Abstract
THE sera of some normal human subjects contain antibodies to human IgG1, and have proved useful in investigating the genetic markers of human IgG (the Gm and Inv factors). But the IgM proteins of different human sera have also been found to differ serologically2, and investigations by means of precipitin systems have led to the designation of possible subclasses3,4. We set out to determine whether normal human sera contain antibodies to human IgM, for such reagents might help the delineation of the structure of the immunoglobulin. We have screened more than two thousand normal human sera for antibodies to IgM; forty-two were found to have such activity.
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