Antibiotic resistance patterns of uropathogens isolated from catheterized and noncatheterized patients in Dhaka, Bangladesh

Abstract

ObjectivesCatheter-associated urinary tract infection (CAUTI) is the most common device-associated nosocomial infection worldwide. Bacteria, which exist as a biofilm inside catheters, show higher antimicrobial resistance when compared to non-CAUTI pathogens. The present study was conducted to determine the antibiotic susceptibility patterns of CAUTI and non-CAUTI bacteria. Materials and MethodsThe antibiotic susceptibility patterns of 102 uropathogens from noncatheterized patients and 100 uropathogens from catheterized patients were compared using the disc diffusion method. ResultsA higher incidence of uropathogens was correlated with catheter use in male patients. Escherichia coli was the predominant isolate obtained from catheterized (81%) and noncatheterized (67%) patients. This was followed by Pseudomonas aeruginosa, with rates of 28% and 15% in non-CAUTI and CAUTI patients, respectively. Overall, the E. coli isolates from CAUTI patients showed significantly higher resistance (p < 0.05) than those from non-CAUTI patients against all antibiotics tested, except for trimethoprim/sulfamethoxazole and gentamicin. Catheter-associated P. aeruginosa isolates showed significantly higher resistance (p < 0.05) against most antibiotics tested compared to non-catheter-associated isolates. ConclusionUropathogens from CAUTI patients exhibit significantly higher resistance to most antibiotics than non-CAUTI isolates. This is an important factor to take into consideration when choosing correct treatment options for patients with urinary tract infection.