Abstract
Introduction: Laparoscopic cholecystectomy is considered as the gold standard treatment for gallstone disease. There has remained a controversy on use of peri operative prophylactic antibiotics during laparoscopic cholecystectomy in reducing perioperative prophylaxis surgical site infections. Various studies has been done to evaluate whether single dose/ three doses or multiple doses are needed to decrease the incidence of surgical site infections. The objective of this study was to identify the incidence of postoperative surgical site infections with three doses of perioperative antibiotics after laparoscopic cholecystectomy. 
 Materials and Methods: This is a retrospective observational study conducted at a private hospital from November 2017 to March 2020. All the patients received three doses of ceftriaxone 1 gram within the first 24 hours of surgery. The incidence of surgical site infection was noted. 
 Results: A total of 449 patients who fulfilled the inclusion criteria were studied. The age ranged from 16 to 88 years. Male to female ratio was 1:4. Seven cases (1.55%) developed postoperative surgical site infections. 
 Conclusion: Three doses of perioperative antibiotics are recommended in laparoscopic cholecystectomy to prevent postoperative surgical site infections.
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