Abstract

Event Abstract Back to Event Anti-biofilm and anti-adherence activities of Spilanthes acmella leaves extracts towards Streptococcus mutans Rohazila Hanafiah1*, Siti Sarah Azhar1, Luqman Atif Elias1 and Siti Aisyah Abd Ghafar1 1 Universiti Sains Islam Malaysia, Malaysia Background Streptococcus mutans is the main causative agents of dental caries by developing biofilm and increase adherence activity. Dental caries have becoming more common due to antibiotic resistance towards Streptococcus mutans. Spilanthes acmella is well-known as anti-toothache plant with high medicinal usages. It has been recognized as an important medicinal plant with high demand worldwide. Therefore, the objective of this study is to establish antimicrobial activities, including anti-biofilm and anti-adherence activity of Spilanthes acmella on cariogenic Streptococcus mutans. Methods Spilanthes acmella leaves extracts were prepared by serial extraction with n-hexane, dichloromethane, acetone and methanol. Antibacterial activities of these extracts were conducted using disc diffusion assay, anti-biofilm and anti-adherence activities methods. Results The result indicates that n-hexane and methanol leaves extracts are endowed with anti-streptococcus activity. Both methanol and n-hexane extracts inhibit moderately Streptococcus mutans growth as indicated in the disc diffusion assay. Methanol and a n-hexane extracts inhibit the biofilm formation and adherence activity of Streptococcus mutans. Conclusion This study highlights the potential of Spilanthes acmella leaves extract as a new promising anti Streptococcus mutans agents. Keywords: Spilanthes acmella, Streptococcus mutans, Anti-biofi lm, Anti-adherence, anti-bacteria Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Hanafiah R, Azhar S, Elias L and Abd Ghafar S (2019). Anti-biofilm and anti-adherence activities of Spilanthes acmella leaves extracts towards Streptococcus mutans. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00057 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Rohazila Hanafiah, Universiti Sains Islam Malaysia, Nilai, Malaysia, rohazila@usim.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rohazila Hanafiah Siti Sarah Azhar Luqman Atif Elias Siti Aisyah Abd Ghafar Google Rohazila Hanafiah Siti Sarah Azhar Luqman Atif Elias Siti Aisyah Abd Ghafar Google Scholar Rohazila Hanafiah Siti Sarah Azhar Luqman Atif Elias Siti Aisyah Abd Ghafar PubMed Rohazila Hanafiah Siti Sarah Azhar Luqman Atif Elias Siti Aisyah Abd Ghafar Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

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