Antibacterial Therapy of Tularemia: Current Status and Prospects

Abstract

The review article includes summarized literature data on experimental evaluation of Francisella tularensis susceptibility to exist­ing antibiotics, and their effectiveness in treatment of tularemia in humans population. The data on ways to improve the effective­ness of some antibacterial drugs that show reduced activity in treatment of tularemia infection are presented. The range of studies aimed at creating modern and more effective antibiotics with new mechanisms of action is defined. A number of methods for mod­ifying variants of the already known groups of antibacterial drugs, as well as ways of prevention or limitation of antibiotic resist­ance formation in F.tularensis are described.