Abstract
In bone surgery and orthopedics, bioresorbable materials can be helpful in bone repair and countering post-op infections. Explicit antibacterial activity, osteoinductive and osteoconductive effects are essential to achieving this objective. Nonwoven electrospun (ES) fibers are receiving the close attention of physicians as promising materials for wound dressing and tissue engineering; potentially, in high contrast with dense materials, ES mats hamper regeneration of the bone extracellular matrix to a lesser extent. The use of the compositions of inherently biodegradable polyesters (poly(ε-caprolactone) PCL, poly(lactoglycolide), etc.), calcium phosphates and antibiotics is highly prospective, but the task of forming ES fibers from such compositions is complicated by the incompatibility of the main organic and inorganic ingredients, polyesters and calcium phosphates. In the present research we report the synthesis of hydroxyapatite (HAp) nanoparticles with uniform morphology, and demonstrate high efficiency of the block copolymer of PCL and poly(ethylene phosphoric acid) (PEPA) as an efficient compatibilizer for PCL/HAp mixtures that are able to form ES fibers with improved mechanical characteristics. The materials obtained in the presence of vancomycin exhibited incremental drug release against Staphylococcus aureus (St. aureus).
Highlights
The progress in bioorganic, inorganic, organic and polymer chemistry resulted in the creation of efficient interdisciplinary techniques proposed for bone treatment, including efficient bone substitution and repair after ‘critical-sized’ bone damage caused by trauma, surgery or infection [1,2,3,4,5]
Of HAp nanoparticles depends the reaction temperadia (Equation (1)) at pH 10–12
We demonstrated a marked efficiency of the use of poly(ethylene phosphoric acid) (PEPA)-containing poly(εCL) compatibilizer for improving the characteristics of PCL/HAp composites
Summary
The progress in bioorganic, inorganic, organic and polymer chemistry resulted in the creation of efficient interdisciplinary techniques proposed for bone treatment, including efficient bone substitution and repair after ‘critical-sized’ bone damage caused by trauma, surgery or infection [1,2,3,4,5]. The desired characteristics of the materials for bone substitution and repair are biocompatibility, osteoinductivity and osteoconductivity, sufficient mechanical strength and antibacterial activity. Substituted hydroxyapatite (HAp) is a base of the main mineral component of bone [6,7,8], which is why materials based on synthetic HAp and other calcium phosphates with given morphologies are highly prospective [9,10,11,12,13], especially in view of the osteoinductive effect of both Ca2+ and PO4 3−.
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