Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida.

Israt J Biva,Hans J Griesser,Chi P Ndi,Susan J Semple

doi:10.3390/antibiotics8020063

Israt J Biva, Hans J Griesser + Show 2 more

Open Access

https://doi.org/10.3390/antibiotics8020063

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Journal: Antibiotics	Publication Date: May 17, 2019
Citations: 13	License type: CC BY 4.0

Affiliation: University of South Australia

Abstract

Plants in the Australian genus Eremophila (Scrophulariaceae) have attracted considerable recent attention for their antimicrobial compounds, which possess a wide range of chemical structures. As they are typically associated with the oily-waxy resin layer covering leaves and green branchlets, and Eremophila lucida is prominent among the species containing a pronounced sticky resin layer, this species was considered of interest for assessing its antibacterial constituents. The n-hexane fraction of the crude acetone extract of the leaves exhibited antibacterial activity against Staphylococcus aureus. Isolation led to the known compounds cembratriene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (1), the sesquiterpenoid, farnesal (2) and the viscidane diterpenoid, 5α-hydroxyviscida-3,14-dien-20-oic acid (3). The purified compounds were tested for antibacterial activity with 2 and 3 showing moderate antibacterial activity against Gram-positive bacteria.

Highlights

There is continuing scientific interest in elucidating the scientific basis for traditional usage of medicinal plants and the potential for identification of new lead antimicrobial compounds
This genus is endemic to Australia and concentrated mainly in arid and semi-arid regions, as suggested by its generic name deriving from the Greek
Phytochemical investigations of species in the genus Eremophila have led to the isolation and identification of over 200 secondary compounds from several classes, with rich diversity in sesqui- and diterpenoids [2]

Summary

Introduction

There is continuing scientific interest in elucidating the scientific basis for traditional usage of medicinal plants and the potential for identification of new lead antimicrobial compounds. This genus is endemic to Australia and concentrated mainly in arid and semi-arid regions, as suggested by its generic name deriving from the Greek. Phytochemical investigations of species in the genus Eremophila have led to the isolation and identification of over 200 secondary compounds from several classes, with rich diversity in sesqui- and diterpenoids [2]. This diversity of secondary compounds and the traditional use of some species has highlighted the pharmacological potential of this genus [3,4,5]. In more recent years biological activities have been found for various Eremophila extracts and isolated secondary compounds, including anti-inflammatory, antimicrobial and cytotoxic activities, and cardioactive effects [2,6,7,8,9,10,11]

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