Abstract
A series of Schiff bases 14–25 were designed and synthesized for evaluation of their antibacterial properties against multi-drug resistant bacteria (MDRB). The antibacterial activities of Schiff bases 14–25 showed that most of the synthesized compounds displayed a significant antibacterial activity. Assessment of in silico ADMET properties (absorption, distribution, metabolism, excretion and toxicity) of Schiff bases illustrates that all derivatives showed agreement to the Lipinski’s rule of five. Further enzymatic assay aided by molecular docking study demonstrated that compound 18 is a potent inhibitor of staphylococcus aureus DNA gyrase and dihydrofolate reductase kinases. This study could be valuable in the discovery of new potent antimicrobial agents.
Highlights
Antibiotics, anti-microbial drugs, and anti-infectious agents are used for treating infectious with micro-organism diseases and able to kill or inhibit the growth of microbes by inhibition of cell membranes synthesis, protein synthesis, nucleic acid synthesis, or cytoplasmic membranes
Schiff bases activities compoundsby[21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39], we have reported in this work seriesaldehydes of Schiff bases was
A series of Schiff bases 14–25 were synthesized by the condensation of in ethanol refluxing
Summary
Antibiotics, anti-microbial drugs, and anti-infectious agents are used for treating infectious with micro-organism diseases and able to kill or inhibit the growth of microbes by inhibition of cell membranes synthesis, protein synthesis, nucleic acid synthesis, or cytoplasmic membranes. Compound 1 demonstrated significant antibacterial activity against S. aureus and. Compound 3 exhibited better antimicrobial activity against S. aureus and S. pyogenes [14]. Compound 3 exhibited better antimicrobial activity against. The azomethine group is found on some marketed drugs e.g., Nifuroxazide (INN) 4 and Thiacetazone tuberculosis (Figure 1). Schiff bases as wellinasthis our target display biological biological activities of compounds [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],ofwe have reported work to a series ofthe.
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