Abstract
Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.
Highlights
Aerogels have been defined as materials composed of more than 99% air; they can be prepared from various organic or inorganic precursors and are often manufactured in multi-shape structures to serve different needs 1
Cellulose-based aerogels have been widely used in many medical applications, such as biosensing, drug delivery, tissue scaffolding, and antibacterial materials for wound dressing
The interest in aerogels just keeps growing as indicated by the number of publications each year. This current review provides an overview on aerogels and their development, we well as discusses the recent works using cellulosebased aerogels for antibacterial delivery
Summary
Aerogels have been defined as materials composed of more than 99% air; they can be prepared from various organic or inorganic precursors and are often manufactured in multi-shape structures to serve different needs 1. Biopolymers and, cellulose have gained a lot of popularity among scientists in terms of aerogel preparation, especially in biomedical applications They have been utilized in wound healing, tissue engineering scaffolds, and drug delivery 3,4. Cellulose-based aerogels have been widely used in many medical applications, such as biosensing, drug delivery, tissue scaffolding, and antibacterial materials for wound dressing. V et al 49 used peptide nanocellulose aerogels for biosensing; they fabricated aerogels with high porosity of 99% to detect protease enzyme activity Their findings in term of mass spectral analysis and the physical properties of prepared aerogels were reported to be suitable for interfacing with an intelligent protease sequestrant wound dressing application. The unique pH and temperature-responsiveness of cellulose-based aerogels, together with their excellent physical, chemical and mechanical properties, as well as their biodegradability, biocompatibility and low cytotoxicity, offer a simple and safe alternative to the conventional systems (synthetic polymers).
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