Abstract
One of the biggest challenges encountered by the medical world is antibiotic resistance posed by the superbugs. Similarly, algae pose a threat by growing in swimming pools, aquariums, causing toxicity in potable waters etc. In this study, a fungal strain was isolated from algal source and studied for its antibiotic activity. The strain was identified as Penicillium purpurogenum var rubrisclerotium and was tested for its antibacterial activity against S.aureus, B.subtillis, E.coli and P.aeruginosa; antialgal activity against Chlorella vulgaris and β-lactamase inhibitor activity against Penicillinase enzyme (B. cereus) using sulbactum as a control for β-lactamase inhibition, and Penicillin as a substrate. The fermented broth exhibited antibacterial, antialgal activity against test cultures along with a significant β-lactamase inhibitory activity, measured by iodometric and agar gel diffusion bioassay methods. The broth was further concentrated by treating it with butyl acetate and tried against test organisms which resulted in many fold increase in the activities.
Published Version
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