Antibacterial and cytotoxicity assay of two new Zn(ii)complexes: Synthesis, characterization, X-Ray structure, topology, Hirshfeld surface and thermal analysis

Abstract

Nano-structures of two mononuclear Zn(II) complexes, [ZnL2Br2] (1) and [ZnL6].2(I) (2) L = 1-methyl imidazole ligand, were synthesized using a sonochemical method and characterized by infrared spectroscopy (IR), UV-Visible, X-Ray powder diffraction (XRPD), scanning electron microscopy (SEM) and elemental analyses. The single-crystal X-ray (SCXA) data of compounds 1 and 2 exhibited different coordination environment of the Zn2+ ions: distorted tetrahedral in 1 and distorted octahedral in 2. The topological analysis showed that compounds 1 and 2 present novel topology for net: 1.4M5–1 and 1.6M7–1, respectively. The thermal stability of compounds 1 and 2 was investigated through differential scanning calorimetry analyses (DSC) and thermal gravimetric analyses (TGA). Nanostructures of zinc(II) oxide was obtained by simultaneous calcination various zinc(II) complexes at 500 °C and, then, were characterized by IR, SEM and XRD. Moreover, the in vitro antibacterial activities of zinc(II) complexes was investigated against gram-positive (S. aureus) and gram-negative (E. coli) bacteria. The results exhibited appropriate antibacterial activities. MTT assay was used for cytotoxicity of the crystals and nanostructures of compounds 1 and 2.