Green approach for fabrication of a novel Zn(II) supramolecular compound as new precursor to produce nano-sized Zinc(II) oxide: Crystallography, topology, Hirshfeld Surface Analysis and biological activities

Abstract

Mononuclear Zinc (II) compound –based nano-structure with [Zn(L)2(CH3COO)2] {as compound 1} formulation was synthesized by reacting ligand 2-Amino-3-Methyl pyridine with Zinc (II) acetate dihydrate and potassium iodide via sonochemical method and characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), infrared spectroscopy (IR) and elemental analyses. Single crystal X-ray diffraction was used to determine the structure of compound 1. The Zn(II) cation has a distorted tetrahedral environment composed of two nitrogen atoms from two 2-amino-3-methyl pyridine ligands and two oxygen atoms from two acetate groups. The topological analysis demonstrated that the topology of compound 1 was 1,2,3,4,4M12–1. The Hirshfeld Surface Analysis (HSA) of the crystal packing of compound 1 was discussed in detail to evaluate the interactions among the crystal packing. Thermal stability of the crystal and nano-structures of compound 1 was investigated using thermal gravimetric analyses (TGA) and differential scanning calorimetry (DSC). Calcination of nano-structures of compound 1 at 550 °C produced zinc(II) oxide, which was subsequently characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and IR spectroscopy. Two strains of gram-negative bacteria (Escherichia coli) and gram-positive bacteria (Staphylococcus aureus) were cultured in the presence of nano-structures of compound 1 to assess their biological activities. This compound displayed sufficient antibacterial activity in an abiotic environment. Cytotoxicity assays of the crystal and nano-structure of compound 1 were performed on L929 human cells. These compounds showed no toxic effect.