Abstract
Screening of Endophytic Bacteria Isolated from Marine Sponge Haliclona fascigera for Inhibition against Clinical Isolates of Methicillin Resistant Staphylococcus aureus (MRSA)Dian Handayani, Neny Sandrawaty, Murniati Murniati, Regina Regina
Highlights
Symbiotic microbes of marine sponge are microbes living in the sponge tissue with mutualism association possibility
The screening result of the cytotoxic activity showed that 76.92 % or 10 fungi isolates were classified as cytotoxic with LC50
The results of the antibacterial activity screening showed that 5 isolates namely NC01, NC03, NC04 NC07 and NC10 could inhibit the growth of pathogenic bacteria by diameter of inhibition zone > 10 mm
Summary
Symbiotic microbes of marine sponge are microbes living in the sponge tissue with mutualism association possibility. Symbiotic microbes of marine sponge could maintain the availability of nutrients for the sponge, stabilize skeleton of sponge, and produce secondary metabolites against pathogenic microbes (Hentschel et al, 2002). Proksch et al, (2002) hypothesized that the symbiotic microbes of marine sponge are original producer of secondary metabolites. Exploration of symbiotic microbes of marine sponge for isolated their secondary metabolites being concern at this time, because they are producer of potential secondary metabolites against various diseases, especially cancer and pathogenic microbial attack (Vasanthabharathi and Jayalakshmi, 2011; Zhou et al, 2014). Among the types of symbiotic microorganisms, symbiotic fungi of sponge is known as a manufacturer of the most interesting bioactive compounds (Bhadury et al, 2006) and Ebel, (2011) explained that the fungi isolated from the marine sponge is one of three main sources to produce new secondary metabolites as anticancer and antimicrobial. The Neopterosia genus had been a major concern as a producer of secondary metabolites, and more than 85 secondary metabolites had been isolated from this sponge (Qaralleh et al, 2016)
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