Abstract
Antioxidants can neutralize free radicals that can affect biological systems in the body that can cause degenerative diseases. Antibacterial active molecules have been identified from plants, and these chemicals are being utilized to develop new and promising treatments. The Mobe plant (Artocarpus lacucha Buch-Ham.) is a species of Artocarpus member of the Moraceae family. Includes a high proportion of phenolic compounds (flavonoids and phenolic acid). This research obtained to know about the biological activity of Artocarpus lacucha Buch-Ham and their total flavonoid and total phenolic content. The extract was prepared using the soxhletation technique using ethanol as the solvent. Antibacterial activity was determined using minimum inhibitor concentration. Propionibacterium acne can be inhibited at concentrations ranging from 300 ppm to 25 ppm. The DPPH technique was used to assess antioxidant activity. The samples’ total flavonoid and phenolic content were measured colorimetrically. The DPPH test revealed an antioxidant activity of 23.33 g/mL, which was used to compute the IC50. The extract’s total phenolic (117.44 mg GAE/g) and flavonoid (3.54 mg QE/g) content were determined to be high.
Highlights
Free radicals are related to cancer, coronary artery disease, hypertension, diabetes, neurological issues, and aging [1,2]
The ability of natural products to give electrons may be evaluated by bleaching them with the 1,1 -diphenyl-1-picrylhydrazyl radical (DPPH) solution [22], which results in a purplecolored solution
Total flavonoids are very effective in scavenging the majority of oxidizing molecules, including singlet oxygen, as well as several free radicals implicated in a variety of diseases [26]
Summary
Free radicals are related to cancer, coronary artery disease, hypertension, diabetes, neurological issues, and aging [1,2]. Plants contain a large number of secondary metabolites such as tannins and lignin, as well as carotenes, flavonoids, and alkaloids, all of which occur in smaller amounts than primary metabolites such as carbohydrate and lipid, which occur in greater abundance in animal and plant tissues Even though these chemicals are non-nutritive, antibacterial activities are believed to exist [4 - 6]. A phenolic is an organic substance containing at least one aromatic ring filled with hydroxyl groups [7] These chemicals have many biological properties, including antioxidant, antibacterial, and anticancer properties, and can be considered a phytomedicine index [8,9]. This research obtained to know about the biological activity of Artocarpus lacucha Buch-Ham and their total flavonoid and total phenolic content
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