Antibacterial and Antimycotic Properties of Modified Carbon Sorbents

Abstract

The aim of the work was to study the biological activity of modifiers and carbon sorbent samples modified by them in relation to some types of microorganisms.Material and methods. The carbon sorbent under study and the modified samples were obtained at the Center of New Chemical Technologies BIC. Glycolic acid, lactic acid, glycine, and glutamic acid were used as modifiers. Strains of Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae 418, Esherichia coli ATCC 25922, Candida albicans (clinical strain) were used as test cultures. The test sample was placed in the wells of a sterile plate, then a working suspension of the test culture was added in the amount of 2.0 ml until completely wet 1:1. The survival of microorganisms was determined by quantitative inoculation from each well of the «sample — microorganism» mixture on Petri dishes with simple nutrient agar using the sector crop method (Gold). The culture species were confirmed by studying their cultural, morphological, and biochemical properties.Results. The conducted studies have demonstrated high antibacterial and antimycotic activity of carbon sorbent samples modified with hydroxyl acids in relation to the most common opportunistic pathogens of pyoinflammatory diseases of bacterial and fungal nature in comparison with the initial sorbent sample. The carbon sorbent modified with lactic acid oligomer showed the highest antibacterial and antimycotic activity.Conclusion. High antibacterial and antimycotic activity of carbon sorbent samples modified with hydroxy acids and amino acids in relation to the most common opportunistic pathogens of pyoinflammatory diseases of bacterial and fungal nature was established in comparison with the initial sample of the sorbent. The carbon sorbent sample modified with amino acids has a pronounced antibacterial effect against all studied bacterial test strains, but exhibits weak antimycotic properties. The use of modified carbon sorbents is a promising direction for the application therapy of pyoinflammatory infections.