ANTIBACTERIAL AND ANTIFUNGAL PROPERTIES OF Zn COMPLEXES WITH N’-ACIL-SALICYLICHYDRAZIDES

Abstract

The antibacterial (Pseudomonas aeruginosa and Mycobacterium phlei) and antifungal (Aspergillus niger, Penicillium Chrysogenium, Penicillium chrosegenum, Cladosporium resinae) properties of Zn complexes with the potentially tridentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment and nitrogen atom of the amide group) N'-phthalimido-salicylamide ligand and potentially heptadentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment, two nitrogen atoms of the hydrazide fragment and two oxygen atoms of the carbonyl and carboxyl groups of the maleic fragment) N'-maleoyl-salicylhydrazide ligand were studied. The antibacterial and antifungal efficacy of the samples was determined by the zonal diffusion method according to GOST 9.085-78. Meat-peptone agar (MPA) was used for growing bacterial cultures, and wort-agar (WA) was used for fungi. These studies have shown that both ligands do not show antibacterial action, but show antifungal action. Zinc complexes of these ligands exhibit both antibacterial and antifungal effects. The antimicrobial action of the complexes is much higher than that of the ligands themselves, and this action increases with an increase in the concentration of complex compounds in solution. The antioxidant effect of the compounds H2L, H4L, (H3L)2Zn, (HL)2Zn synthesized by us was studied in cumene oxidation reactions - cumene autoxidation and reactions with cumene peroxide. Establishing the mechanism of action as an inhibitor or antioxidant that prevents oxidation as a result of the presence of the above compounds was studied in the study of cumene autoxidation