Abstract
The influence of 5 new Platinum(IV) (Pt(IV)) complexes with S-alkyl derivatives of thiosalicylic acid (C1-benzyl, C2-methyl, C3-ethyl, C4-propyl and C5- butyl) was studied on 16 strains of bacteria. Antibacterial activity was tested using microdilution method with resazurin while antibiofilm activity was observed by tissue culture plate method, using doxycycline as a positive control. The results were expressed as minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and biofilm inhibitory concentration (BIC). The best result on Gram positive bacteria exhibited C1 and MIC was <7.81μg/ml against Staphylococcus aureus ATCC 25923. Bifidobacterium animalis subsp. lactis (probiotic) was sensitive to C2 (MIC at 15.625 μg/ml). The highest sensitivity of Gram negative bacteria was observed in Escherichia coli ATCC 25922 treated with C1, C2, C3 and C4, in Proteus mirabilis ATCC 12453 treated with C1, and in Pseudomonas aeruginosa treated with C2, C3 and C5 (all MICs at 250 μg/ml). The C2 complex were more efficient as antibiofilm agents and the best results were obtained with C2 acting against S. aureus and S. aureus ATCC 25923 biofilms. In conclusion, we noticed that the tested compounds exhibited promising properties as antibacterial and antibiofilm agents.
Highlights
The interest in determining the influence of new metal complexes on microorganisms is increasing due to the growing resistance of pathogenic bacteria
Antibacterial activity was tested using microdilution method with resazurin while antibiofilm activity was observed by tissue culture plate method, using doxycycline as a positive control
The highest sensitivity of Gram negative bacteria was observed in Escherichia coli ATCC 25922 treated with C1, C2, C3 and C4, in Proteus mirabilis ATCC 12453 treated with C1, and in Pseudomonas aeruginosa treated with C2, C3 and C5
Summary
The interest in determining the influence of new metal complexes on microorganisms is increasing due to the growing resistance of pathogenic bacteria. Square planar Pd (II) and octahedral Pt (IV) complexes with novel spherical aramides nanoparticles containing flexible linkages ligands were tested for antimicrobial activity (ELHUSSEINY and HASSAN, 2013). In this investigation, Pt complexes as polymeric nanoparticles showed high potency as antitumor and antimicrobial agents. Pt(IV) complexes with unsymmetrical tetradentate schiff bases (HEGAZY and GAAFAR, 2012) have been tested on Bacillus subtilis, S. aureus, Escherichia coli, Salmonella typhi, yeast and fungi. They have proven to act as antimicrobials. Other studies of platinum (Pt(IV)) complexes include Pt(IV) chelate (HEGAZY, 2012), Pt(IV) dithiocarbamate complexes (MANAV et al, 2006), thiodiamines with Pt(IV) (MISHRA and KAUSHIK, 2007), etc
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
