Abstract
Acinetobacter baumannii has emerged as a problematic nosocomial pathogen due to its antibiotic resistance as well as its ability to colonize and cause serious infection among patients. This study aimed to evaluate the ability of Acinetobacter baumannii to form biofilms as well as to investigate the antibacterial activity of cinnamaldehyde against carbapenem-resistant strains of A. baumannii. A total of 23 Acinetobacter baumannii clinical strains were screened for their ability to form a biofilm using tissue culture plate method. Cinnamaldehyde antibacterial ability was investigated on planktonic cells and its biofilm inhibition ability was tested. Scanning electron microscopy (SEM) was applied to confirm the antibiofilm effect of cinnamaldehyde. Biofilm formers (86.95 %) were categorized into strong (17.39%), moderate (52.17 %), weak (17.39 %). Cinnamaldehyde showed strong antimicrobial activity against planktonic cells of A. baumannii at low concentrations. The best antibiofilm activity was achieved at ½ MIC and ¼ MIC causing inhibition percentage ranging from 49.5% to 71.2% and 18.5% to 29.6% respectively. Cinnamaldehyde exerted strong antimicrobial and antibiofilm properties indicating their potential therapeutic value that can be used as an option for treating biofilm associated clinical problems caused by Acinetobacter baumannii.
Highlights
Acinetobacter baumannii (A. baumannii) is a wellknown pathogen which is responsible for hospital-acquired infections due to its remarkable ability to survive in the hospital environment as well as its rapidly acquire resistance determinants agents (Bogdan et al, 2017)
This study aimed to evaluate the ability of A. baumannii to form biofilms as well as to investigate the antibacterial activity of cinnamaldehyde against carbapenemresistant strains of A. baumannii
The best antibiofilm activity was achieved at 1⁄2 minimum inhibitory concentration (MIC) and 1⁄4 MIC causing inhibition percentages ranging from 49.5% to 71.2% and 18.5% to 29.6%, respectively
Summary
Acinetobacter baumannii (A. baumannii) is a wellknown pathogen which is responsible for hospital-acquired infections due to its remarkable ability to survive in the hospital environment as well as its rapidly acquire resistance determinants agents (Bogdan et al, 2017). Treatment options for MDR A. baumannii are extremely limited as a result for its resistant to most antimicrobial agents including carbapenems (Bae et al, 2016; Hu et al, 2017). Many natural compounds, such as plant extracts and secondary metabolites have been evaluated for antimicrobial activity (Nowotarska et al, 2017), and within this group, essential oils (EOs) are the most important members. Our study was designed to evaluate the ability of A. baumannii to form biofilms as well as investigate the antimicrobial and antibiofilm activities of the cinnamaldehyde on clinical isolates of carbapenem-resistant A. baumannii
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
