Abstract
Objective To analyze antibiotic resistance and molecular epidemiological characteristics of Acinetobacter baumannii hospital infection. Methods A total of 39 strains of Acinetobacter baumannii were isolated during March and April in 2014 and antibiotic resistance was detected and analyzed. Meanwhile, pulsed-field gel electrophoresis (PFGE) was used to perform the molecular epidemiological analysis and cluster analysis software to compare the homology of Acinetobacter baumannii. Results There were 37 clinical isolates in total 39 Acinetobacter baumannii strains, which were mainly isolated from sputum in ICU patients. The positive rate of carbapenem-resistant Acinetobacte rbaumannii (CRAB) , multi-drug resisitant Acinetobacter baumannii (MDRAB) and extensively drug resistant Acinetobacter baumannii (XDRAB) in 39 strains were 74.4%, 56.4% and 25.6%, respectively. Pan drug resistant Acinetobacter baumannii and tigecycline-resistant strains had not been found, while 9 mediation strains were found and the intermediary rate was 23.1%. The antibiotics with resistance rates over 70% were ciprofloxacin (82.1%) , ceftriaxone (79.5%) , gentamicin (76.9%) , cefepime (74.4%) , imipenem (74.4%) and piperacillin/tazobactam (71.8%) , respectively. Resistance rate of cefoperazone/sulbactam was 13.5%.Cluster analysis of PFGE pattern showed that 39 strains of Acinetobacter baumannii were divided into 17 types, which were distributed mostly in surgical ICU, including A-type, C-type, J-type and M-type Acinetobacter baumannii clones, following by the medical ICU and neonatal ICU with O-type and P-type epidemic strains. Consistent homology of Acinetobacter baumannii isolated from various departments existed between aspirator switch and patient samples. Conclusions With higher detection rate, CRAB, MDRAB and XDRAB strains spread widely and even cause outbreak of epidemic with A-type, C-type and J-type as the main clones in some ICU wards. The aspirator switch may be an important medium for the cross infection of Acinetobacter baumannii in ICU wards. Key words: Acinetobacter baumannii; Hospital infection; Molecular epidemiology; Cluster analysis
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call