Abstract
In this work, Ni and SnO2loaded Chitosan nanomaterials are prepared by neutralization method, obtained by drop wise addition of Chitosan solution to a solution of NaOH, followed by cross-linking. The Structural, morphological and Raman analyses are carried out. The antibacterial activity is analysed against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa and evaluated by the calculation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The obtained results show that, Ni-loaded nanoparticles could inhibit the growth of various bacteria better than SnO2. These results revealed that, the exposure of Staphylococcus aureus to the Chitosan nanoparticles led to the disruption of cell membranes and the leakage of cytoplasm.
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