Antibacterial activity of zinc oxide nanoparticles obtained by pulsed laser ablation in water and air

Daria Goncharova,Anna Nemoykina,Ekaterina Gavrilenko,Valery Svetlichnyi,A Vorozhtsov

doi:10.1051/matecconf/201824300017

Daria Goncharova, Anna Nemoykina + Show 3 more

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https://doi.org/10.1051/matecconf/201824300017

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Abstract

The paper studies physicochemical and antibacterial properties of ZnO nanoparticles obtained by pulsed laser ablation in water and air. Their composition and structure were studied by X-ray diffraction, transmission and scanning electron microscopy. Antibacterial activity of the nanoparticles was examined by its affection on Gram-positive Staphylococcus aureus (S.aureus). The dependence of nanoparticles’ physical and chemical antibacterial properties on the conditions of the ablation was shown. The model materials for the antibacterial bandage were made of cotton, filter paper and biodegradable polymer scaffolds (poly-l-lactide acid), and then they were coated with the obtained ZnO nanoparticles. The model bandage materials were examined by the scanning electron microscopy method and their antibacterial activity (ISO 20743:2013) was determined. High activity of all the samples against S.aureus was proved.

Highlights

One of the problems of modern medicine is the fight against antibiotic-resistant bacterial strains
The purpose of this paper is to present the results of study of the physicochemical and antibacterial properties of ZnO nanopowders obtained by the Zn pulsed laser ablation method (PLA) target in water and air
Nanopowders obtained by pulsed laser ablation of a zinc target in water and air are compared in this paper

Summary

Introduction

One of the problems of modern medicine is the fight against antibiotic-resistant bacterial strains. S.aureus is the main causative agent of purulent surgical infections. The resistance to S.aureus is observed among 70% of patients with purulent infection, because their microflora is resistant to penicillin, streptomycin, chlortetracycline, laevomycetin and erythromycin. That is why its necessary to develop new generations of antibiotics and other agents to suppress bacterial infections. In this case nanotechnology can support medical industry. There is an urgent problem connected with the creation of nonremovable bandage based on biodegradable polymers [2, 3] with prolonged antibacterial action for the treatment and prevention of purulent infections of wounds of various origins, especially in the field conditions

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