Antibacterial activity of methanol leaves extract against Uropathogens

Abstract

One of the reasons diseases are re-emerging is due to multidrug-resistant strains of bacteria in the environment because of overuse of antibiotics. The conventional antibiotics are losing their efficacy against the strains that they used to work against. These prevailing conditions push us towards the pursuit of finding new antimicrobial agents. They might prove to be the solution for the problem under consideration. In this study, we investigated the antimicrobial activity of leaf extracts against a panel of pathogenic microorganisms. The leaves were extracted using methanol and the antimicrobial activity was evaluated using agar disc diffusion method. Our results demonstrated significant antimicrobial potential for the methanol extract, with pronounced inhibition against both gram-positive and gram-negative bacteria, including This assay suggests their potential application as therapeutic agents. Moreover, the phytochemical analysis indicated the presence of bioactive compounds, such as alkaloids, flavonoids, and phenolic compounds, which may contribute to their antimicrobial efficacy. These findings highlight leaf extracts as promising sources of natural antimicrobial agents that could be developed into novel therapeutics to combat AMR and enhance public health. However, further research is needed to elucidate the underlying mechanisms of action and evaluate their safety and efficacy in clinical settings.