Abstract
In this work, the antibacterial activity of silver nanoparticles (AgNPs) synthesized using Areca catechu extracts against three species of antibiotic-susceptible and three species of resistant bacteria was investigated. The effects of this plant were more promising when compared with other medicinal plants tested. The hydrothermal extract of Areca catechu was mixed with silver nitrate to synthesize AgNPs. The synthesized particle characteristics were analyzed by UV–Vis spectrophotometry, scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FT-IR). Minimum inhibitory concentration and minimum bactericidal concentration tests were conducted to confirm antibacterial activity and the results showed that AgNPs synthesized using Areca catechu extracts effectively inhibited the growth of bacterial species. Moreover, the SEM images of the bacterial species treated with AgNPs synthesized with Areca catechu extracts showed that clusters of AgNPs were attached to the surface of the bacterial cell wall, which could induce destruction of the cell membranes. The results suggest that AgNPs synthesized with Areca catechu extracts have the potential to treat antibiotic-resistant bacteria known as the major cause of nosocomial infections.
Highlights
Published: 14 January 2021Antibiotic-resistant bacteria are a worldwide problem that has emerged due to the misuse and long-term administration of antibiotics
The Areca catechu extract demonstrated good performance, so the characteristics of the synthesized particles were estimated by various experimental methods and antibacterial activity against antibiotic-resistant bacteria was confirmed
The results of this study confirmed that A. catechu extract could be used to effectively synthesize AgNPs
Summary
Antibiotic-resistant bacteria are a worldwide problem that has emerged due to the misuse and long-term administration of antibiotics. Nanoparticles are small substances of 1 to 100 nm in size They can provide solutions for technical problems such as next-generation energy use, environmental pollution, and medication for incurable diseases due to their physical and biological properties [2]. AgNPs synthesized by physical and chemical methods can lead to environmental pollution, toxic effects on the human body, technological problems, high cost, and low efficiency [4,5]. To solve these problems, biological approaches that use ecofriendly and non-toxic chemicals in the synthetic process are gaining attention. The Areca catechu extract demonstrated good performance, so the characteristics of the synthesized particles were estimated by various experimental methods and antibacterial activity against antibiotic-resistant bacteria was confirmed
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