Abstract
Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and human pathogenic bacteria with eight newly synthesized Schiff bases and several intermediate silyl compounds have been reported. The antibacterial activities of the synthesized compounds were primarily determined by paper disc diffusion method. The minimum inhibitory concentration (MIC) of each compound was also determined by tube dilution process. Seven different human pathogenic bacteria and eighteen different plant pathogenic bacteria were used for the antibacterial activity studies. While all synthesized compounds have shown significant antibacterial activity, one intermediate silyl compound has shown remarkably high antibacterial property. 5-substituted derivatives have shown relatively higher activity than non-substituted compounds. Polar substituent which increases hydrophilicity may have a positive impact on the antibacterial property.
Highlights
Schiff base, named after Hugo Schiff, is another name of iminie functional groups or azomethine groups (-C=N) that are classically formed by condensation of a primary amine with an aldehyde or ketone [1]
Preparation of test microorganism The sterilized medium was poured into sterilized petri dish (500 ml for 20 petri dishes) and solidified (1.5%, w/v agar) at room temperature for 30 min. 18 different types of plant pathogenic and 7 human pathogenic bacterial strains were used in this study of both gram positive and gram negative bacteria
The following Tables show the name of the compounds and antibacterial activity according to the inhibition zones in mm scale
Summary
Schiff base, named after Hugo Schiff, is another name of iminie functional groups or azomethine groups (-C=N) that are classically formed by condensation of a primary amine with an aldehyde or ketone [1]. Since various Schiff bases and their complexes have been formed and exhibited promising activity against bacteria and other microorganism, biochemists are interested to study Schiff bases for their medical importance and use in design of medicinal compounds [2] [3]. Many Schiff bases have antimicrobial and antifungal activities [4]. Aryl groups or heterocyclic residues containing Schiff bases possess excellent biological activities [5] [6]. Phenanthroline and its derivatives have significantly antibacterial, antifungal and anticancer activity [7]. Phenanthroline complexes exhibited high cytotoxicity in cancer cell lines, even sometimes higher activity than cis-platin and substitution at 5- or 5,6-position increases cytotoxicity such as the S, S isomer of complex is 100-fold more cytotoxic than of cis-platin in L2110 murine leukemia cell lines [11]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call