Antibacterial Ability of Mesoporous Carbonated Hydroxyapatite

Abstract

Mesoporous carbonated hydroxyapatite (Meso-CHA) is a bioceramic materials that offer good biocompatibility and bioactivity properties that suitable for bone defects or diseases treatment and therapy. Antibacterial study is very important to ensure that materials is biocompatible enough to be used on or inside the human body. The aim of this study is to investigate the antibacterial ability of the Meso-CHA (without addition of antibacterial agents) towards Escherichia coli (E. coli) bacteria. Meso-CHA samples were synthesized using chemical precipitation method where surfactant P-123 was used to introduce pores within nanoparticles structure. X-ray Diffraction (XRD) and Fourier Transform Infrared (FTIR) analysis proved that pure phase of Meso-CHA was obtained. Synthesized Meso-CHA demonstrated higher pore properties (surface area = 146.92 m2g−1, pore size = 2.35 nm, and pore volume = 0.2437 cm3g−1) compared to commercial HA (surface area = 7.84 m2 g−1, pore size = 2.05 nm, and pore volume = 0.0085 cm3 g−1). The antibacterial study demonstrated that Meso-CHA has low antibacterial properties with Minimum Inhibitory Concentration (MIC) of 200 mg.ml−1 compared to HA. Carbonate ion addition into the Meso-CHA structure does not improve the antibacterial ability of the materials.