Abstract
Clematis orientalis has been used traditionally to cure rheumatism, but its efficacy has not been scientifically explored in treating rheumatoid arthritis. The present study was designed to investigate the antiarthritic efficacy of C. orientalis using blockade of heat-induced protein alterations and HRBC membrane stabilization methods along with formaldehyde induced arthritis in rats. Aqueous ethanol (30:70) extract and various fractions (hexane, n-butanol and aqueous) produced concentration-dependent and significant (p<0.001) inhibition of protein (egg albumin and bovine serum albumin) denaturation and red blood cell membrane stabilization at 50-6400 ug/mL concentration. Similarly in formaldehyde induced arthritis plant extract and fractions revealed the considerable reduction in paw swelling and its diameter at doses of 50, 100 and 200 mg/kg with maximum (p<0.001) effect at the highest dose. Thus present findings imply that aqueous ethanol extract as well as different fractions of C. orientalis has noteworthy antiarthritic potential supporting its folkloric use in inflammatory arthritic conditions.
Highlights
Arthritis is a chronic inflammatory disorder affecting primarily joints and it affects about 1-2% of the populace worldwide
The aqueous ethanolic extract was prepared by cold maceration technique
Findings of present investigation have revealed that aqueous ethanolic extract and various fractions of C. orientalis dose-dependently exert antiarthritic effects
Summary
Arthritis is a chronic inflammatory disorder affecting primarily joints and it affects about 1-2% of the populace worldwide. Rheumatoid arthritis is an unremitting multisystem disease accompanied by immune hyperactivity, persistent synovitis, and synovial hyperplasia along with deposition of autoantibodies to immunoglobulins leading to articular cartilage annihilation and resorption of osseous matter. Current therapeutic modalities are not curative but provide symptomatic relief reducing pain, inflammation, articular damage, functional impairment and systemic complications. Notwithstanding the substantial progress in current therapy of joint problems, exploration for newer drugs continues because the existing synthetic drugs are devoid of satisfactory treatment. Current therapeutic modalities are allied with considerable toxic profile leading to the inclination of public attention towards herbal remedies (Baranwal et al, 2012)
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