Abstract
Taurine (2-aminoethane sulfonic acid), a ß-amino acid present in human diet, is one of the most abundant sulfur containing amino acids in mammalian tissues, found in excess of 30 µmol/g tissue in rat heart1,2. Taurine exhibits a variety of cardiovascular pharmacological activity, including membrane stabilizing effects, inotropic actions and hypotensive activity. Recently, evidence has been obtained indicating that taurine also attenuates isoprenaline-induced free radical production. Although some investigators have reported that taurine is an antiarrhythmic agent3,4, the precise mechanism underlying this action has not been established. In the present study, we examined the effects of taurine on arrhythmias caused by adrenaline infusion, ischemia-reperfusion injury and veratrine administration in anesthetized rats. We also have explored the relationship between the antiarrhythmic activity of taurine and changes in myocardial cAMP and free radical production.
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