Abstract
Objective To investigate the anti–anaphylactic, anti–inflammatory and membrane stabilizing properties of plumerianine (compound 1) isolated from the root bark of Plumeria acutifolia Poir. Methods The anti–anaphylactic activity of compound 1 (10, 25 and 50 mg/kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and its anti–inflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs. Results A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum. The compound 1 also exhibited significant ( P<0.01) inhibition of rat paw edema and granuloma tissue formation, including significant protection of RBC against the haemolytic effect of hypotonic solution, an indication of membrane-stabilizing activity. Conclusions Anti–anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators. Anti–inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.
Highlights
Allergic disorders are in rise every year and stated as an endemic disease of the 21st century
In the present paper we report the anti-anaphylactic, anti-inflammatory and membrane stabilizing activities of the isolated compound
In the study on passive cutaneous anaphylaxis model, compound 1 produced a significant dose dependent decrease in the amount of evans blue dye leaked at site when compared with control
Summary
Allergic disorders are in rise every year and stated as an endemic disease of the 21st century. Some of the allergic disorders, which may be caused by an allergen originating from immune system, environment, and by genes, are,asthma, eczema, hay fever, anaphylaxis, autoimmune disorders [1]. A number of plants are described in Ayurveda for use in the treatment of allergic disorders, namely psoriasis, eczema, bronchial asthma, etc. Mast cells immediately released the preformed and the de novo synthesized mediators such as histamine, proteases, leukotrienes, prostaglandins, and cytokines[2]. Allergic responses trigger the influx and activation of a variety of inflammatory cells including eosinophils and lymphocytes. Released mediators and numerous cytokines produced by mast cells are strongly believed to induce and sustain these responses, which may contribute to chronic inflammation
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