Abstract
• A facile and green synthesis of nanoparticles of Watermelon seeds is proposed. • No chemical precursors or surfactants were used. • The nanoparticles exhibited profound antibacterial and antiproliferative activity. • It is a potential novel nutraceutical with a prospective role in cancer therapy. Watermelon ( Citrullus lanatus ) seeds are endowed with phytonutrients that ascribe to their potent antioxidant status. The present study proposes a facile and novel green synthesis of nanoparticles of the seed extract. The synthesized nanoparticles showed a mean average size of 215 nm with a single significant peak and a polydispersity index (PDI) of 0.11.The electron micrographs showed spherical nanoparticles dispersed without agglomeration The biocidal and the antiproliferative effect on cancer cell lines (HCT-116, HepG-2, HeLa) of the nanoparticles (WMnano) was more pronounced as compared to the bulk seed extract (WMS).
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