Abstract
In order to search for new lead compounds with anti-phytopathogenic bacterial activity, three pairs of new furanone derivatives, sclerotiorumins D–F (1–3), and eight known compounds (4–11) were isolated from the seaweed-derived fungus, Aspergillus sp. D40, fermented with potato dextrose seawater (PDW) medium. Their structures were determined using comprehensive spectroscopic analyses including HRESIMS , 1D and 2D NMR data. Compounds 1–4 and 9 existed as inseparable mixtures of a pair of epimers. Penicillic acid (7) exhibited clear antibacterial activity against Ralstonia solanacearum and several other plant pathogenic bacteria with IC50 values ranging from 11.6 to 58.2 µg/mL.
Highlights
Phytopathogenic bacteria cause many serious diseases in plants and limit the quality and production of crops all over the world, and as a result pose a significant threat to global food safety (Sundin et al, 2016)
A few – mainly chemical – pesticides are used to control phytopathogenic bacteria, this leads to environmental pollution, pesticide residues, food safety issues, and pathogen resistance (Fujiwara et al, 2011)
It is well known that marine fungi can produce secondary metabolites with novel structures and potential antibacterial activities, as part of their repertoire of survival strategies and metabolic mechanisms endowed by the unique marine environment
Summary
Phytopathogenic bacteria cause many serious diseases in plants and limit the quality and production of crops all over the world, and as a result pose a significant threat to global food safety (Sundin et al, 2016). R. solanacearum affects more than 200 plant species belonging to over 50 different botanical families, including Solanaceae – tomato and potato – and many weeds, crops, shrubs, and trees (dicot as well as monocot) This pathogen invades the xylem conduit from the roots of the plant, and spreads to the aerial parts of the plant through the vascular system. It is well known that marine fungi can produce secondary metabolites with novel structures and potential antibacterial activities, as part of their repertoire of survival strategies and metabolic mechanisms endowed by the unique marine environment. They have been a hotspot for study of new antibacterial agents (Carroll et al, 2020). We report the isolation, identification, and antibacterial activity of these compounds
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