Abstract
Objective: The current study evaluates anti-Parkinson’s activity of aqueous extracts of leaves of Murraya koenigii (MK) (AEMK) against paraquat (PQ)-induced Parkinsonism in rats.
 Methods: In this study, effects of MK (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters such as catalepsy, muscle rigidity, and locomotor activity and its effects on neurochemical parameters malondialdehyde, catalase (CAT), glutathione (GSH) reductase, GSH peroxidase, and GSH in rats.
 Results: Parkinson’s disease was induced by administering PQ 10 mg/kg b.w/i.p once in a week for 4 weeks. The increased cataleptic scores were significantly (p<0.001) found to be reduced, with the AEMK in a dose-dependent manner. Chronic administration of PQ significantly induced motor dysfunction (muscle rigidity and hypolocomotion), showed a significant increase in lipid peroxidation level, and depleted the levels of GSH, CAT, and reduced GSH. Daily administration of AEMK significantly improved motor performance and also significantly attenuated oxidative damage.
 Conclusion: The study proved that MK treatment significantly attenuated motor defects and also protected the brain from oxidative stress.
Highlights
Neurodegenerative disorder (ND) results in a loss or death of neurons [1]
The novelty of this work was to analyze the aqueous extract of Murraya koenigii (MK) (AEMK) against PQ-induced Parkinsonism in rats to avoid shortcomings of conventional dosage forms
A dose-dependent protection of the activities was observed after treatment with aqueous extract of leaves of MK before PQ intoxication
Summary
Neurodegenerative disorder (ND) results in a loss or death of neurons [1]. It occurs due to oxidative stress, neurotoxins, serious trauma, and few long-term treatments with medications [2]. Parkinson’s disease (PD) is a chronic progressive NO [3] of the central nervous system. Murraya koenigii (MK) is used as a stimulant, stomachic, febrifuge, analgesic and for the treatment of diarrhea, dysentery, insect bites, anti-tumor, antimicrobial, anti-inflammatory [4], antibacterial, and antifungal activity [5]. MK is used in the treatment of neurodegenrative disorders like PD. MK is evaluated for its anti-Parkinson’s effect using neurotoxin-induced Parkinson’s model in rats. The novelty of this work was to analyze the aqueous extract of MK (AEMK) against PQ-induced Parkinsonism in rats to avoid shortcomings of conventional dosage forms
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