Abstract
Anti‐obesity effects of dietary supplemented amino acid have been reported. Dietary supplementation of glutamine, alanine, or leucine decreases high‐fat diet induced obesity in C57BL/6J mice. It was reported that histidine supplementation suppressed food intake and fat accumulation in Wistar rats. And it was shown that dietary arginine supplementation reduced fat mass in Zucker diabetic fatty rats. However there is no information about the anti‐obesity effects of other amino acids than above mentioned. Therefore, we conducted this series of experiments to compare the anti‐obesity effects of 20 kinds of proteinogenic amino acids. Male C57BL/6J mice were fed a high‐fat diet supplemented with either one of 20 proteinogenic amino acids (1‐6 %) for 4 to 8 weeks. Body weight, food intake, epididymal fat weight, and plasma triglyceride concentration were measured. Results showed that supplementation with any one of cystine (3%), histidine (5%), leucine (3%), lysine HCl (3%), threonine (3%), and tryptophan (3%) suppressed body weight gain and visceral fat deposition. Reduction of food intake was observed in cystine and histidine group but not in leucine, lysine, threonine, and tryptophan group. Plasma triglyceride concentration reduced only in lysine group. In conclusion, dietary supplementation of any one of leucine, lysine, threonine, and tryptophan prevents high‐fat diet induced obesity without reduction in food intake, which suggests increased energy expenditure. Among these amino acids, lysine is the most potent amino acid to reduce adiposity, since it decreases diet induced obesity as well as hyperlipidemia.
Published Version
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